Sleep disruption is linked to social interactive difficulties. But does sleep loss affect social interactive learning? Here, we show that a lack of sleep did not lead to poor interactive learning. Contrarily, learners interacting with instructors are compensated after sleep loss (i.e., they maintain a comparable learning level as that following a normal sleep) during learning algorithmic procedures. This compensatory effect is explained by the increased interpersonal synchronization of inferior frontal cortices (IFC) between instructors and learners. In particular, it is the instructor who synchronizes with learner rather than vice versa. Moreover, IFC (seed) - based intrinsic brain network strengthens during learning. We propose that brain coupling mechanisms, especially interpersonal brain synchronization, in inferior frontal regions provide a means of compensation after sleep loss for social cognitive processing, thereby likely supporting interactive learning.