• wednesday, 9 january 2019—12:15

    Tristan BEKINSCHTEIN - Cognitive dynamics of sleep and sedation transitions

    Tristan BEKINSCHTEIN, University of Cambridge

    The main goals of this line of research is to characterise the behaviour
    and neurodynamics of the transitions from awake to asleep and from
    awake to sedated (and back) by means of auditory decision-making tasks.
    To this end we employed behavioural measures, high-density
    electroencephalography (EEG), EEG combined with functional magnetic
    resonance (EEG-fMRI), and intracranial recordings (local field
    potentials in epileptic patients). Varying several parameters in these
    tasks has allowed us to start to understand the changes of attentional
    resources, working memory and decision-making abilities during these
    transitions. The characterization of such integrative processes using
    the same paradigms during sleep and anaesthesia transitions helps us
    understand the differences and commonalities between being conscious,
    semi-conscious and unconscious states. In short, as we fall asleep we
    seem to be able to take some decisions deeper into sleep but others
    fragment early on, we continue to take semantic decisions even during
    sleep, difficult decisions shift from perceptual to central integration
    processes when drowsy, we have less efficient decision-making with
    sedation but auditory processes only follow drug concentration, and
    sedation modulates the information between perceptual and attention
    processes. The transition is a powerful model to understand the
    fragmentation of cognitive process, thus revealing its mechanisms.

    external seminar