wednesday, 18 january 2023—12:15
Heard but not present: Pathophysiology of prediction and adaptation
Sonja Kotz, Neuropsychology & Psychopharmacology, Maastricht University
In a continuously changing environment, we rely on prior knowledge to evaluate actual against expected sensations (predictions) and adapt to mismatches between these sensations. Pathological changes in the auditory system (e.g., deafferentation in tinnitus, aberrant sensory feedback in auditory verbal hallucinations) might lead to new default predictions that show as altered suppression and/or enhancing irrelevant sound. I will present animal and human studies on tinnitus and auditory hallucinations as examples of adaptive distortions in tone and voice processing. These data showcase the critical contribution of cortico-cerebello-thalamo-cortical circuitry in maintaining and adjusting predictions.